PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26204832-0 2015 Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways. sinulariolide 0-13 AKT serine/threonine kinase 1 Homo sapiens 151-154 26204832-6 2015 Sinulariolide also exerted an inhibitory effect on phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), phosphatidylinositol 3-kinase (PI3K), Akt, Focal adhesion kinase (FAK), growth factor receptor-bound protein 2 (GRB2). sinulariolide 0-13 AKT serine/threonine kinase 1 Homo sapiens 185-188 26204832-7 2015 Taken together, these results demonstrated that sinulariolide could inhibit hepatocellular carcinoma cell migration and invasion and alter HA22T cell metastasis by reduction of MMP-2, MMP-9, and uPA expression through the suppression of MAPKs, PI3K/Akt, and the FAK/GRB2 signaling pathway. sinulariolide 48-61 AKT serine/threonine kinase 1 Homo sapiens 249-252