PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25963742-0	2015	CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit.	Toluene	51-58	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6	
25963742-1	2015	BACKGROUND: CYP2E1 is a versatile phase I drug-metabolizing enzyme responsible for the biotransformation of most volatile organic compounds, including toluene.	Toluene	151-158	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	12-18	
25963742-2	2015	Human toluene exposure increases CYP2E1 mRNA and modifies its activity in leucocytes; however, epigenetic implications of this interaction have not been investigated.	Toluene	6-13	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	33-39	
25963742-3	2015	GOAL: To determine promoter methylation of CYP2E1 and other genes known to be affected by toluene exposure.	Toluene	90-97	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	43-49	
25963742-6	2015	RESULTS: In exposed group we found significant correlations between toluene airborne levels and CYP2E1 promoter methylation (r=-.36, p<0.05), as well as for IL6 promoter methylation levels (r=.44, p<0.05).	Toluene	68-75	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	96-102	
25963742-7	2015	Moreover, CYP2E1 promoter methylation levels where higher in toluene-exposed smokers compared to nonsmokers (p=0.009).	Toluene	61-68	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	10-16	
25963742-9	2015	CONCLUSION: These results highlight the importance of considering CYP2E1 epigenetic modifications, as well as its interactions with other genes, as key factors for unraveling the sub cellular mechanisms of toxicity exerted by oxidative stress, which can initiate disease process in chronic, low-level toluene exposure.	Toluene	301-308	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	66-72	
25963742-10	2015	People co-exposed to toluene and tobacco smoke are in higher risk due to a possible CYP2E1 repression.	Toluene	21-28	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-90