PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25963742-0 2015 CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit. Toluene 51-58 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 25963742-1 2015 BACKGROUND: CYP2E1 is a versatile phase I drug-metabolizing enzyme responsible for the biotransformation of most volatile organic compounds, including toluene. Toluene 151-158 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 12-18 25963742-2 2015 Human toluene exposure increases CYP2E1 mRNA and modifies its activity in leucocytes; however, epigenetic implications of this interaction have not been investigated. Toluene 6-13 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 33-39 25963742-3 2015 GOAL: To determine promoter methylation of CYP2E1 and other genes known to be affected by toluene exposure. Toluene 90-97 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 43-49 25963742-6 2015 RESULTS: In exposed group we found significant correlations between toluene airborne levels and CYP2E1 promoter methylation (r=-.36, p<0.05), as well as for IL6 promoter methylation levels (r=.44, p<0.05). Toluene 68-75 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 96-102 25963742-7 2015 Moreover, CYP2E1 promoter methylation levels where higher in toluene-exposed smokers compared to nonsmokers (p=0.009). Toluene 61-68 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 10-16 25963742-9 2015 CONCLUSION: These results highlight the importance of considering CYP2E1 epigenetic modifications, as well as its interactions with other genes, as key factors for unraveling the sub cellular mechanisms of toxicity exerted by oxidative stress, which can initiate disease process in chronic, low-level toluene exposure. Toluene 301-308 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 66-72 25963742-10 2015 People co-exposed to toluene and tobacco smoke are in higher risk due to a possible CYP2E1 repression. Toluene 21-28 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 84-90