PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25945035-0 2015 Promoting endothelial function by S-nitrosoglutathione through the HIF-1alpha/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. S-Nitrosoglutathione 34-54 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 67-77 25945035-0 2015 Promoting endothelial function by S-nitrosoglutathione through the HIF-1alpha/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. S-Nitrosoglutathione 34-54 vascular endothelial growth factor A Rattus norvegicus 78-82 25945035-3 2015 Using a rat model of cerebral ischemia and reperfusion (IR) in this study, we tested the hypothesis that GSNO invokes the neurorepair process and improves neurobehavioral functions through the angiogenic HIF-1alpha/VEGF pathway. S-Nitrosoglutathione 105-109 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 204-214 25945035-3 2015 Using a rat model of cerebral ischemia and reperfusion (IR) in this study, we tested the hypothesis that GSNO invokes the neurorepair process and improves neurobehavioral functions through the angiogenic HIF-1alpha/VEGF pathway. S-Nitrosoglutathione 105-109 vascular endothelial growth factor A Rattus norvegicus 215-219 25945035-5 2015 The injured animals were treated with saline (IR group, n=7), GSNO (0.25 mg/kg, GSNO group, n=7), and GSNO plus the HIF-1alpha inhibitor 2-methoxyestra-diol (2-ME) (0.25 mg/kg GSNO + 5.0 mg/kg 2-ME, GSNO + 2-ME group, n=7). 2-Methoxyestradiol 137-156 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 116-126 25945035-7 2015 Brain capillary endothelial cells were used to show that GSNO promotes angiogenesis and that GSNO-mediated induction of VEGF and the stimulation of angiogenesis are dependent on HIF-1alpha activity. S-Nitrosoglutathione 93-97 vascular endothelial growth factor A Rattus norvegicus 120-124 25945035-7 2015 Brain capillary endothelial cells were used to show that GSNO promotes angiogenesis and that GSNO-mediated induction of VEGF and the stimulation of angiogenesis are dependent on HIF-1alpha activity. S-Nitrosoglutathione 93-97 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 178-188 25945035-9 2015 GSNO treatment of IR not only remarkably enhanced further the expression of HIF-1alpha, VEGF, and PECAM-1 but also improved functioning compared with IR. S-Nitrosoglutathione 0-4 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 76-86 25945035-9 2015 GSNO treatment of IR not only remarkably enhanced further the expression of HIF-1alpha, VEGF, and PECAM-1 but also improved functioning compared with IR. S-Nitrosoglutathione 0-4 vascular endothelial growth factor A Rattus norvegicus 88-92 25945035-9 2015 GSNO treatment of IR not only remarkably enhanced further the expression of HIF-1alpha, VEGF, and PECAM-1 but also improved functioning compared with IR. S-Nitrosoglutathione 0-4 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 98-105 25945035-11 2015 Increased expression of VEGF and the degree of tube formation (angiogenesis) by GSNO were reduced after the inhibition of HIF-1alpha by 2-ME in an endothelial cell culture model. S-Nitrosoglutathione 80-84 vascular endothelial growth factor A Rattus norvegicus 24-28 25945035-11 2015 Increased expression of VEGF and the degree of tube formation (angiogenesis) by GSNO were reduced after the inhibition of HIF-1alpha by 2-ME in an endothelial cell culture model. S-Nitrosoglutathione 80-84 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 122-132 25945035-11 2015 Increased expression of VEGF and the degree of tube formation (angiogenesis) by GSNO were reduced after the inhibition of HIF-1alpha by 2-ME in an endothelial cell culture model. 2-Methoxyestradiol 136-140 vascular endothelial growth factor A Rattus norvegicus 24-28 25945035-11 2015 Increased expression of VEGF and the degree of tube formation (angiogenesis) by GSNO were reduced after the inhibition of HIF-1alpha by 2-ME in an endothelial cell culture model. 2-Methoxyestradiol 136-140 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 122-132 25945035-12 2015 2-ME treatment of the GSNO group also blocked not only GSNO"s effect of reduced infarct volume, decreased neuronal loss, and enhanced expression of PECAM-1 (P<0.001), but also its improvement of motor and neurological functions (P<0.001). 2-Methoxyestradiol 0-4 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 148-155 25945035-12 2015 2-ME treatment of the GSNO group also blocked not only GSNO"s effect of reduced infarct volume, decreased neuronal loss, and enhanced expression of PECAM-1 (P<0.001), but also its improvement of motor and neurological functions (P<0.001). S-Nitrosoglutathione 22-26 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 148-155 25945035-12 2015 2-ME treatment of the GSNO group also blocked not only GSNO"s effect of reduced infarct volume, decreased neuronal loss, and enhanced expression of PECAM-1 (P<0.001), but also its improvement of motor and neurological functions (P<0.001). S-Nitrosoglutathione 55-59 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 148-155 25945035-13 2015 CONCLUSION: GSNO stimulates the process of neurorepair, promotes angiogenesis, and aids functional recovery through the HIF-1alpha-dependent pathway, showing therapeutic and translational promise for stroke. S-Nitrosoglutathione 12-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 120-130