PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25908095-2	2015	Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38).	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 14	Homo sapiens	112-115	
25908095-2	2015	Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38).	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 14	Homo sapiens	155-158	
25908095-3	2015	Blocking p38 MAPK activation prevents REGgamma elevation in HaCaT cells with TPA treatment.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 14	Homo sapiens	9-12	
25908095-4	2015	AP-1, the downstream effector of MAPK/p38, directly binds to the REGgamma promoter and activates its transcription in response to TPA stimulation.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase 14	Homo sapiens	38-41	
25908095-6	2015	Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 14	Homo sapiens	17-20