PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25879420-10 2015 Shikonin also induced the mitochondrial apoptotic pathway mediated through the enhanced expression of the pro-apoptotic Bax and inhibition of Bcl-2, disruption of the mitochondrial membrane potential (MMP) followed by the activation of caspase-9, caspase-3, and PARP cleavage. shikonin 0-8 caspase 9 Homo sapiens 236-245