PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25872771-0	2015	Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain.	sapropterin	72-75	BCL2 like 1	Homo sapiens	51-57	
25872771-2	2015	Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), while Bcl-XL, likely independently of its BH4 domain, sensitizes IP3Rs.	sapropterin	191-194	BCL2 apoptosis regulator	Homo sapiens	0-5	
25872771-5	2015	Mammalian protein-protein interaction trap (MAPPIT) and surface plasmon resonance (SPR) showed that Bcl-XL bound to the central domain of RyR3 via its BH4 domain, although to a lesser extent compared to the BH4 domain of Bcl-2.	sapropterin	151-154	BCL2 like 1	Homo sapiens	100-106	
25872771-5	2015	Mammalian protein-protein interaction trap (MAPPIT) and surface plasmon resonance (SPR) showed that Bcl-XL bound to the central domain of RyR3 via its BH4 domain, although to a lesser extent compared to the BH4 domain of Bcl-2.	sapropterin	151-154	ryanodine receptor 3	Homo sapiens	138-142	
25872771-5	2015	Mammalian protein-protein interaction trap (MAPPIT) and surface plasmon resonance (SPR) showed that Bcl-XL bound to the central domain of RyR3 via its BH4 domain, although to a lesser extent compared to the BH4 domain of Bcl-2.	sapropterin	207-210	ryanodine receptor 3	Homo sapiens	138-142	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	35-38	BCL2 like 1	Homo sapiens	49-55	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	35-38	BCL2 like 1	Homo sapiens	89-95	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	35-38	ryanodine receptor 3	Homo sapiens	109-113	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	35-38	ryanodine receptor 2	Rattus norvegicus	67-70	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	85-88	BCL2 like 1	Homo sapiens	49-55	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	85-88	BCL2 like 1	Homo sapiens	89-95	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	85-88	ryanodine receptor 3	Homo sapiens	109-113	
25872771-6	2015	Consistent with the ability of the BH4 domain of Bcl-XL to bind to RyRs, loading the BH4-Bcl-XL peptide into RyR3-overexpressing HEK293 cells or in rat hippocampal neurons suppressed RyR-mediated Ca(2+) release.	sapropterin	85-88	ryanodine receptor 2	Rattus norvegicus	67-70