PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25724183-4	2015	Further, cinobufotalin inhibited sphingosine kinase 1 (SphK1) activity and induced pro-apoptotic ceramide production.	cinobufotalin	9-22	sphingosine kinase 1	Homo sapiens	33-53	
25724183-4	2015	Further, cinobufotalin inhibited sphingosine kinase 1 (SphK1) activity and induced pro-apoptotic ceramide production.	cinobufotalin	9-22	sphingosine kinase 1	Homo sapiens	55-60	
25724183-5	2015	Ceramide synthase-1 small hairpin RNA (shRNA)-depletion inhibited cinobufotalin-induced ceramide production and HCC cell apoptosis.	cinobufotalin	66-79	ceramide synthase 1	Homo sapiens	0-19	
25724183-5	2015	Ceramide synthase-1 small hairpin RNA (shRNA)-depletion inhibited cinobufotalin-induced ceramide production and HCC cell apoptosis.	Ceramides	88-96	ceramide synthase 1	Homo sapiens	0-19	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	RV 538	65-113	UDP-glucose ceramide glucosyltransferase	Homo sapiens	23-48	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	RV 538	65-113	UDP-glucose ceramide glucosyltransferase	Homo sapiens	50-53	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	RV 538	115-119	UDP-glucose ceramide glucosyltransferase	Homo sapiens	23-48	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	RV 538	115-119	UDP-glucose ceramide glucosyltransferase	Homo sapiens	50-53	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	cinobufotalin	133-146	UDP-glucose ceramide glucosyltransferase	Homo sapiens	23-48	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	cinobufotalin	133-146	UDP-glucose ceramide glucosyltransferase	Homo sapiens	50-53	
25724183-6	2015	On the other hand, the glucosylceramide synthase (GCS) inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitated cinobufotalin-induced ceramide production and cell apoptosis.	Ceramides	31-39	UDP-glucose ceramide glucosyltransferase	Homo sapiens	50-53	
25724183-7	2015	SphK1 inhibitor II (SKI-II), similar to cinobufotalin, increased cellular ceramide level and promoted HCC cell apoptosis.	Ceramides	74-82	sphingosine kinase 1	Homo sapiens	0-5	
25724183-8	2015	Finally, we observed that cinobufotalin inactivated Akt-S6K1 signaling in HepG2 cells, which was again inhibited by ceramide synthase-1 shRNA-depletion.	cinobufotalin	26-39	ceramide synthase 1	Homo sapiens	116-135