PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25652588-4 2015 We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage. Tetradecanoylphorbol Acetate 115-151 ADAM metallopeptidase domain 10 Homo sapiens 296-302 25652588-4 2015 We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage. Tetradecanoylphorbol Acetate 153-156 ADAM metallopeptidase domain 10 Homo sapiens 296-302