PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25544427-4 2015 Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. Paclitaxel 165-170 interleukin 6 Homo sapiens 13-17 25544427-4 2015 Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. Paclitaxel 165-170 interleukin 6 Homo sapiens 24-28 25544427-4 2015 Silencing of IL-6 using IL-6 siRNA was found to suppress IL-6 production, STAT3 and phosphoSTAT3 levels, which eventually reduced proliferation and clonogenicity of taxol-resistant SKOV3/TR cells. Paclitaxel 165-170 interleukin 6 Homo sapiens 24-28 25544427-5 2015 In addition, stattic, a STAT3 inhibitor, was found to result in decrease of cell viability and clonogenicity of these cells, indicating that the elevated IL-6 and STAT3, phosphoSTAT3 levels are associated with the development of taxol resistance. Paclitaxel 229-234 interleukin 6 Homo sapiens 154-158 25544427-10 2015 Taken together, our data suggest that inhibition of IL-6/STAT3 signaling pathway and downregulation of Axl and Tyro3 RTKs expression might be a therapeutic strategy to overcome taxol resistance in ovarian cancer cells. Paclitaxel 177-182 interleukin 6 Homo sapiens 52-56