PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25313747-6 2014 RESULTS: Increased vascularization in CAM, increased endothelial sprouting in rat aortic rings in culture, and increased expression of CD31 and E-selectin suggested a possible angiogenic effect of sarcosine. Sarcosine 197-206 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus 135-139 25313747-6 2014 RESULTS: Increased vascularization in CAM, increased endothelial sprouting in rat aortic rings in culture, and increased expression of CD31 and E-selectin suggested a possible angiogenic effect of sarcosine. Sarcosine 197-206 selectin E Rattus norvegicus 144-154 25313747-7 2014 Sarcosine modulated expression of angiogenic growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). Sarcosine 0-9 vascular endothelial growth factor A Homo sapiens 68-102 25313747-7 2014 Sarcosine modulated expression of angiogenic growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). Sarcosine 0-9 vascular endothelial growth factor A Homo sapiens 104-108 25313747-8 2014 In ECs in culture LY294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt pathway and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) reversed the effect of sarcosine. Sirolimus 97-106 mechanistic target of rapamycin kinase Homo sapiens 124-153 25313747-8 2014 In ECs in culture LY294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt pathway and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) reversed the effect of sarcosine. Sarcosine 184-193 mechanistic target of rapamycin kinase Homo sapiens 124-153 25313747-9 2014 Further, sarcosine induced upregulation and activation of Akt in HUVECs. Sarcosine 9-18 AKT serine/threonine kinase 1 Homo sapiens 58-61 25313747-10 2014 CONCLUSION: These results suggest that sarcosine modulates EC function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway. Sarcosine 39-48 AKT serine/threonine kinase 1 Homo sapiens 123-126 25313747-10 2014 CONCLUSION: These results suggest that sarcosine modulates EC function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway. Sarcosine 39-48 mechanistic target of rapamycin kinase Homo sapiens 127-131