PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25059554-0	2014	Nicotine induces the production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human periodontal ligament cells: an in vitro study.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	35-43	
25059554-6	2014	RESULTS: Compared with the control group, nicotine could significantly induce production of IL-1beta and IL-8 in human PDL cells and cause the similar effects on the expression of the NF-kappaB p65 subunit and NF-kappaB activity.	Nicotine	42-50	interleukin 1 beta	Homo sapiens	92-100	
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	77-85	
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	232-240	interleukin 1 beta	Homo sapiens	77-85