PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24971153-0	2014	Lycopene Inhibits Urotensin-II-Induced Cardiomyocyte Hypertrophy in Neonatal Rat Cardiomyocytes.	Lycopene	0-8	urotensin 2	Rattus norvegicus	18-30	
24971153-1	2014	This study investigated how lycopene affected urotensin-II- (U-II-) induced cardiomyocyte hypertrophy and the possible implicated mechanisms.	Lycopene	28-36	urotensin 2	Rattus norvegicus	46-58	
24971153-1	2014	This study investigated how lycopene affected urotensin-II- (U-II-) induced cardiomyocyte hypertrophy and the possible implicated mechanisms.	Lycopene	28-36	urotensin 2	Rattus norvegicus	61-66	
24971153-3	2014	The lycopene (3-10  mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression.	Lycopene	4-12	urotensin 2	Rattus norvegicus	67-71	
24971153-3	2014	The lycopene (3-10  mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression.	Lycopene	4-12	urotensin 2	Rattus norvegicus	135-139	
24971153-4	2014	Lycopene further inhibited the U-II-induced phosphorylation of the redox-sensitive extracellular signal-regulated kinases.	Lycopene	0-8	urotensin 2	Rattus norvegicus	31-35	
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	urotensin 2	Rattus norvegicus	165-169	
24971153-7	2014	These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment.	Lycopene	26-34	urotensin 2	Rattus norvegicus	182-186	
24971153-8	2014	Thus, the data indicate that lycopene prevented U-II-induced cardiomyocyte hypertrophy through a mechanism involving the inhibition of redox signaling.	Lycopene	29-37	urotensin 2	Rattus norvegicus	48-52