PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24944202-3	2014	cAMP formation was tightly regulated via feedback phosphorylation of AC5/6 and PDE4D5 by PKA.	Cyclic AMP	0-4	adenylate cyclase 5	Mus musculus	69-74	
24944202-3	2014	cAMP formation was tightly regulated via feedback phosphorylation of AC5/6 and PDE4D5 by PKA.	Cyclic AMP	0-4	phosphodiesterase 4D, cAMP specific	Mus musculus	79-84	
24944202-5	2014	TNBS treatment in vivo and IL-1beta and TNF-alpha in vitro induced inducible nitric oxide synthase (iNOS) expression, stimulated ERK1/2 activity, caused iNOS-mediated S-nitrosylation and inhibition of AC5/6, and induced phosphorylation of PDE4D5 and stimulated its activity.	Trinitrobenzenesulfonic Acid	0-4	nitric oxide synthase 2, inducible	Mus musculus	67-98	
24944202-5	2014	TNBS treatment in vivo and IL-1beta and TNF-alpha in vitro induced inducible nitric oxide synthase (iNOS) expression, stimulated ERK1/2 activity, caused iNOS-mediated S-nitrosylation and inhibition of AC5/6, and induced phosphorylation of PDE4D5 and stimulated its activity.	Trinitrobenzenesulfonic Acid	0-4	nitric oxide synthase 2, inducible	Mus musculus	100-104	
24944202-5	2014	TNBS treatment in vivo and IL-1beta and TNF-alpha in vitro induced inducible nitric oxide synthase (iNOS) expression, stimulated ERK1/2 activity, caused iNOS-mediated S-nitrosylation and inhibition of AC5/6, and induced phosphorylation of PDE4D5 and stimulated its activity.	Trinitrobenzenesulfonic Acid	0-4	mitogen-activated protein kinase 3	Mus musculus	129-135	
24944202-5	2014	TNBS treatment in vivo and IL-1beta and TNF-alpha in vitro induced inducible nitric oxide synthase (iNOS) expression, stimulated ERK1/2 activity, caused iNOS-mediated S-nitrosylation and inhibition of AC5/6, and induced phosphorylation of PDE4D5 and stimulated its activity.	Trinitrobenzenesulfonic Acid	0-4	nitric oxide synthase 2, inducible	Mus musculus	153-157	
24944202-5	2014	TNBS treatment in vivo and IL-1beta and TNF-alpha in vitro induced inducible nitric oxide synthase (iNOS) expression, stimulated ERK1/2 activity, caused iNOS-mediated S-nitrosylation and inhibition of AC5/6, and induced phosphorylation of PDE4D5 and stimulated its activity.	Trinitrobenzenesulfonic Acid	0-4	adenylate cyclase 6	Mus musculus	201-206	
24944202-6	2014	The resultant decrease in AC5/6 activity and increase in PDE4D5 activity decreased cAMP formation and smooth muscle relaxation.	Cyclic AMP	83-87	adenylate cyclase 6	Mus musculus	26-31	
24944202-6	2014	The resultant decrease in AC5/6 activity and increase in PDE4D5 activity decreased cAMP formation and smooth muscle relaxation.	Cyclic AMP	83-87	phosphodiesterase 4D, cAMP specific	Mus musculus	57-62	
24944202-7	2014	S-nitrosylation and inhibition of AC5/6 activity were reversed by the iNOS inhibitor 1400W, whereas phosphorylation and activation of PDE4D5 were reversed by the phosphatidylinositol 3-kinase inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	85-90	adenylate cyclase 6	Mus musculus	34-39	
24944202-7	2014	S-nitrosylation and inhibition of AC5/6 activity were reversed by the iNOS inhibitor 1400W, whereas phosphorylation and activation of PDE4D5 were reversed by the phosphatidylinositol 3-kinase inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	85-90	nitric oxide synthase 2, inducible	Mus musculus	70-74	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Colforsin	40-49	interleukin 1 beta	Mus musculus	15-23	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Colforsin	40-49	tumor necrosis factor	Mus musculus	27-36	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Colforsin	40-49	adenylate cyclase 6	Mus musculus	129-134	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Cyclic AMP	61-65	interleukin 1 beta	Mus musculus	15-23	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Cyclic AMP	61-65	tumor necrosis factor	Mus musculus	27-36	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Cyclic AMP	61-65	adenylate cyclase 6	Mus musculus	129-134	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	197-202	interleukin 1 beta	Mus musculus	15-23	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	197-202	tumor necrosis factor	Mus musculus	27-36	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	197-202	adenylate cyclase 6	Mus musculus	129-134	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	interleukin 1 beta	Mus musculus	15-23	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	tumor necrosis factor	Mus musculus	27-36	
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	adenylate cyclase 6	Mus musculus	129-134