PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24927258-0	2014	Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma cells with functional p53 deficiency and resistance to EGFR blockade.	Arsenic Trioxide	54-70	tumor protein p53	Homo sapiens	120-123	
24927258-4	2014	The causal relationship between p53 deficiency and ATO sensitivity was evaluated by reconstitution of wildtype p53 in p53-deficient SCCHN cells.	Arsenic Trioxide	51-54	tumor protein p53	Homo sapiens	32-35	
24927258-4	2014	The causal relationship between p53 deficiency and ATO sensitivity was evaluated by reconstitution of wildtype p53 in p53-deficient SCCHN cells.	Arsenic Trioxide	51-54	tumor protein p53	Homo sapiens	111-114	
24927258-4	2014	The causal relationship between p53 deficiency and ATO sensitivity was evaluated by reconstitution of wildtype p53 in p53-deficient SCCHN cells.	Arsenic Trioxide	51-54	tumor protein p53	Homo sapiens	111-114	
24927258-6	2014	RESULTS: Functional rather than structural defects in the p53 gene predisposed tumor cells to increased sensitivity to ATO.	Arsenic Trioxide	119-122	tumor protein p53	Homo sapiens	58-61	
24927258-7	2014	Reconstitution of wt p53 in p53-deficient SCCHN cells rendered them less sensitive to ATO treatment.	Arsenic Trioxide	86-89	tumor protein p53	Homo sapiens	21-24	
24927258-7	2014	Reconstitution of wt p53 in p53-deficient SCCHN cells rendered them less sensitive to ATO treatment.	Arsenic Trioxide	86-89	tumor protein p53	Homo sapiens	28-31	
24927258-9	2014	The inhibitory effect of ATO in p53-deficient tumor cells was mainly associated with DNA damage, G2/M arrest, upregulation of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) receptors and apoptosis.	Arsenic Trioxide	25-28	tumor protein p53	Homo sapiens	32-35	
24927258-11	2014	CONCLUSIONS: Addition of ATO to treatment regimens for p53-deficient SCCHN and tumor recurrence after cetuximab-containing regimens might represent an attractive strategy in SCCHN.	Arsenic Trioxide	25-28	tumor protein p53	Homo sapiens	55-58