PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24845459-1 2014 Autoantibodies to inosine monophosphate dehydrogenase-2 (IMPDH2), an enzyme involved in de novo biosynthesis of guanine nucleotides, are observed in a subset of hepatitis C virus (HCV) patients receiving interferon alpha (IFN-alpha) plus ribavirin. Ribavirin 238-247 inosine monophosphate dehydrogenase 2 Homo sapiens 57-63 24845459-9 2014 In conclusion, this study showed that the temporal kinetics of IFN-alpha + ribavirin-induced humoral autoimmune response to IMPDH2 exhibited a considerably delayed pace of increase in antibody levels and avidity as well as in isotype class switch in comparison with a conventional humoral response to infectious agents. Ribavirin 75-84 inosine monophosphate dehydrogenase 2 Homo sapiens 124-130