PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24841429-4 2014 In the present study, we explored some mechanisms associated with resistance to tamoxifen, such as pharmacologic mechanisms, loss or modification in estrogen receptor expression, alterations in co-regulatory proteins and the regulation of the different signaling pathways that participate in different cellular processes such as survival, proliferation, stress, cell cycle, inhibition of apoptosis regulated by the Bcl-2 family, autophagy, altered expression of microRNA, and signaling pathways that regulate the epithelial-mesenchymal transition in the tumor microenvironment. Tamoxifen 80-89 BCL2 apoptosis regulator Homo sapiens 415-420