PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24836981-5	2014	We determined the role of ROS generation in mediating increases in IL-1beta secretion through caspase-1 activation caused by NLRP3 inflammasome activation in an environment-induced murine dry eye (DE) model.	Reactive Oxygen Species	26-29	interleukin 1 beta	Mus musculus	67-75	
24836981-7	2014	Increases in ROS production preceded rises in corneal and conjunctival gene expression of NLRP3 inflammasome components and IL-1beta that were identified using real-time PCR.	Reactive Oxygen Species	13-16	interleukin 1 beta	Mus musculus	124-132	
24836981-10	2014	Rises in ROS generation occurred after 1 week of ICES exposure, which preceded increases in gene expression of three NLRP3 inflammasome components (i.e. NLRP3, ASC and caspase-1) leading to rises in bioactive IL-1beta release.	Reactive Oxygen Species	9-12	interleukin 1 beta	Mus musculus	209-217	
24836981-16	2014	We show in a dessicating DE disease murine model that rises in ROS generation trigger NLRP3 inflammasome complexation and activation leading to increases in bioactive IL-1beta secretion.	Reactive Oxygen Species	63-66	interleukin 1 beta	Mus musculus	167-175	
24836981-17	2014	These results prompt us to suggest that the ROS-NLRP3-IL-1beta signaling pathway might play a priming role in environment-induced DE progression.	Reactive Oxygen Species	44-47	interleukin 1 beta	Mus musculus	54-62