PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24612036-3 2014 The challenge of differentiated SK-N-BE human neuroblastoma cells with patho-physiologically relevant amounts of 27-OH and 24-OH showed that both oxysterols induce a net synthesis of Abeta1-42 by up-regulating expression levels of amyloid precursor protein and beta-secretase, as well as the beta-secretase activity. Oxysterols 146-156 amyloid beta precursor protein Homo sapiens 231-256 24612036-5 2014 The reported findings link an impaired cholesterol oxidative metabolism to an excessive beta-amyloidogenesis and point to NAC as an efficient inhibitor of oxysterols-induced Abeta toxic peptide accumulation in the brain. Oxysterols 155-165 amyloid beta precursor protein Homo sapiens 174-179