PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24361399-13 2014 Finally, experiments using T47D (wild-type p53) and MDA-MB-435 (mutant p53) cell lines suggested that tamoxifen induces p53-independent ROS production as well as p53-dependent senescence in breast cancer cells. Tamoxifen 102-111 tumor protein p53 Homo sapiens 43-46 24361399-13 2014 Finally, experiments using T47D (wild-type p53) and MDA-MB-435 (mutant p53) cell lines suggested that tamoxifen induces p53-independent ROS production as well as p53-dependent senescence in breast cancer cells. Tamoxifen 102-111 tumor protein p53 Homo sapiens 71-74 24361399-13 2014 Finally, experiments using T47D (wild-type p53) and MDA-MB-435 (mutant p53) cell lines suggested that tamoxifen induces p53-independent ROS production as well as p53-dependent senescence in breast cancer cells. Tamoxifen 102-111 tumor protein p53 Homo sapiens 71-74 24361399-13 2014 Finally, experiments using T47D (wild-type p53) and MDA-MB-435 (mutant p53) cell lines suggested that tamoxifen induces p53-independent ROS production as well as p53-dependent senescence in breast cancer cells. Tamoxifen 102-111 tumor protein p53 Homo sapiens 71-74 24361399-14 2014 SIGNIFICANCE: These results demonstrate that tamoxifen promotes senescence through a ROS-p53-p21(Cip1/WAF1) dependent pathway by inhibiting CK2 activity in breast cancer and colon cancer cells. Tamoxifen 45-54 tumor protein p53 Homo sapiens 89-92