PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24287900-7 2013 Our results showed that: (1) both autophagy and apoptosis could be induced by treatment with matrine; (2) using the autophagic inhibitor chloroquine and beclin-1 small-interfering RNA, cell apoptosis induced by matrine could be enhanced in a caspase-dependent manner; and (3) autophagy was induced via inhibition of PI3K/AKT/mTOR pathway and up-regulation of beclin-1. Chloroquine 137-148 AKT serine/threonine kinase 1 Homo sapiens 321-324