PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24269216-0 2014 Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion. (6-((4'-(3,4-dihydroxybutoxy)-2,2',6'-trimethyl(1,1'-biphenyl)-3-yl)methoxy)-3H-spiro(1-benzofuran-2,1'-cyclopropan)-3-yl)acetic acid 20-29 free fatty acid receptor 1 Mus musculus 6-11 24269216-0 2014 Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion. Glucose 39-46 free fatty acid receptor 1 Mus musculus 6-11 24269216-0 2014 Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion. Sitagliptin Phosphate 98-109 free fatty acid receptor 1 Mus musculus 6-11 24269216-4 2014 MAIN METHODS: We evaluated acute glucose metabolism on insulin and GLP-1 secretion using an oral glucose tolerance test (OGTT) as well as assessed the chronic glucose metabolism in diabetic ob/ob mice following the repeated administration of AS2575959. Glucose 33-40 glucagon Mus musculus 67-72 24269216-6 2014 Further, we observed a synergistic effect of AS2575959 and DPP-IV inhibitor on insulin secretion and plasma GLP-1 level. (6-((4'-(3,4-dihydroxybutoxy)-2,2',6'-trimethyl(1,1'-biphenyl)-3-yl)methoxy)-3H-spiro(1-benzofuran-2,1'-cyclopropan)-3-yl)acetic acid 45-54 glucagon Mus musculus 108-113