PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23904909-0	2013	Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.	baicalein	109-118	AKT serine/threonine kinase 1	Rattus norvegicus	42-45	
23904909-0	2013	Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.	baicalein	109-118	erythropoietin	Rattus norvegicus	83-86	
23904909-0	2013	Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.	baicalein	109-118	vascular endothelial growth factor A	Rattus norvegicus	91-95	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	arachidonate 15-lipoxygenase	Rattus norvegicus	81-99	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	arachidonate 15-lipoxygenase	Rattus norvegicus	101-110	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	237-246	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	270-288	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	290-294	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	318-348	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	30-39	AKT serine/threonine kinase 1	Rattus norvegicus	356-359	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	180-189	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	237-246	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	180-189	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	270-288	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	180-189	egl-9 family hypoxia-inducible factor 1	Rattus norvegicus	290-294	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	180-189	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	318-348	
23904909-1	2013	The neuroprotective effect of baicalein is generally attributed to inhibition of 12/15-lipoxygenase (12/15-LOX) and suppression of oxidative stress, but recent studies showed that baicalein also activates hypoxia-inducible factor-alpha (HIF1alpha) through inhibition of prolyl hydrolase 2 (PHD2) and activation of the phosphatidylinositide-3 kinase (PI3K)/Akt signaling pathway.	baicalein	180-189	AKT serine/threonine kinase 1	Rattus norvegicus	356-359	
23904909-2	2013	Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1alpha, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown.	baicalein	175-184	erythropoietin	Rattus norvegicus	62-76	
23904909-2	2013	Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1alpha, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown.	baicalein	175-184	erythropoietin	Rattus norvegicus	78-81	
23904909-2	2013	Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1alpha, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown.	baicalein	175-184	vascular endothelial growth factor A	Rattus norvegicus	87-121	
23904909-2	2013	Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1alpha, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown.	baicalein	175-184	vascular endothelial growth factor A	Rattus norvegicus	123-127	
23904909-2	2013	Yet, the significance and regulation of prosurvival cytokines erythropoietin (Epo) and vascular endothelial growth factor (VEGF), two transcriptional targets of HIF1alpha, in baicalein-mediated neuroprotection in neurons and astrocytes remains unknown.	baicalein	175-184	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	161-170	
23904909-4	2013	Our results show that baicalein induced Epo and VEGF expression in a HIF1alpha- and PI3K/Akt-dependent manner in neurons.	baicalein	22-31	erythropoietin	Rattus norvegicus	40-43	
23904909-4	2013	Our results show that baicalein induced Epo and VEGF expression in a HIF1alpha- and PI3K/Akt-dependent manner in neurons.	baicalein	22-31	vascular endothelial growth factor A	Rattus norvegicus	48-52	
23904909-4	2013	Our results show that baicalein induced Epo and VEGF expression in a HIF1alpha- and PI3K/Akt-dependent manner in neurons.	baicalein	22-31	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	69-78	
23904909-4	2013	Our results show that baicalein induced Epo and VEGF expression in a HIF1alpha- and PI3K/Akt-dependent manner in neurons.	baicalein	22-31	AKT serine/threonine kinase 1	Rattus norvegicus	89-92	
23904909-5	2013	Baicalein also protected neurons against excitotoxicity in a PI3K- and Epo/VEGF-dependent manner without affecting neuronal excitability.	baicalein	0-9	erythropoietin	Rattus norvegicus	71-74	
23904909-5	2013	Baicalein also protected neurons against excitotoxicity in a PI3K- and Epo/VEGF-dependent manner without affecting neuronal excitability.	baicalein	0-9	vascular endothelial growth factor A	Rattus norvegicus	75-79	
23904909-6	2013	In contrast, at least a 10-fold higher concentration of baicalein was needed to induce Epo/VEGF production and PI3K/Akt activity in astrocytes for protection of neurons.	baicalein	56-65	erythropoietin	Rattus norvegicus	87-90	
23904909-6	2013	In contrast, at least a 10-fold higher concentration of baicalein was needed to induce Epo/VEGF production and PI3K/Akt activity in astrocytes for protection of neurons.	baicalein	56-65	vascular endothelial growth factor A	Rattus norvegicus	91-95	
23904909-6	2013	In contrast, at least a 10-fold higher concentration of baicalein was needed to induce Epo/VEGF production and PI3K/Akt activity in astrocytes for protection of neurons.	baicalein	56-65	AKT serine/threonine kinase 1	Rattus norvegicus	116-119	
23904909-7	2013	Moreover, only baicalein-induced astrocytic VEGF, but not Epo expression requires HIF1alpha, while PI3K/Akt signaling had little role in baicalein-induced astrocytic Epo/VEGF expression.	baicalein	15-24	vascular endothelial growth factor A	Rattus norvegicus	44-48	
23904909-8	2013	These results suggest distinct mechanisms of baicalein-mediated Epo/VEGF production in neurons and astrocytes for neuroprotection, and provide new insights into the mechanisms and potential of baicalein in treating brain injury in vivo.	baicalein	45-54	erythropoietin	Rattus norvegicus	64-67	
23904909-8	2013	These results suggest distinct mechanisms of baicalein-mediated Epo/VEGF production in neurons and astrocytes for neuroprotection, and provide new insights into the mechanisms and potential of baicalein in treating brain injury in vivo.	baicalein	45-54	vascular endothelial growth factor A	Rattus norvegicus	68-72