PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23717422-6 2013 In addition, sanguinarine effectively increased the activation of the c-Jun N-terminal kinase (JNK) and the expression of the early growth response gene-1 (Egr-1), which was recovered by pretreatment with NAC. sanguinarine 13-25 early growth response 1 Homo sapiens 156-161 23717422-7 2013 Furthermore, knockdown of Egr-1 expression by small interfering RNA attenuated sanguinarine-induced apoptosis, but not the JNK inhibitor, indicating that the interception of ROS generation blocked the sanguinarine-induced apoptotic effects via deregulation of the expression of Egr-1 proteins. sanguinarine 79-91 early growth response 1 Homo sapiens 26-31 23717422-7 2013 Furthermore, knockdown of Egr-1 expression by small interfering RNA attenuated sanguinarine-induced apoptosis, but not the JNK inhibitor, indicating that the interception of ROS generation blocked the sanguinarine-induced apoptotic effects via deregulation of the expression of Egr-1 proteins. sanguinarine 201-213 early growth response 1 Homo sapiens 26-31