PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23500541-0 2013 Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKbeta leading to autophagy. Deoxyglucose 40-54 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 105-114 23500541-0 2013 Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKbeta leading to autophagy. Glucose 47-54 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 105-114 23500541-4 2013 Here, we find that ER stress induced by 2-DG as well as tunicamycin activates AMPK via Ca2+-CaMKKbeta leading to stimulation of autophagy. Deoxyglucose 40-44 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 92-101 23500541-4 2013 Here, we find that ER stress induced by 2-DG as well as tunicamycin activates AMPK via Ca2+-CaMKKbeta leading to stimulation of autophagy. Tunicamycin 56-67 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 92-101 23500541-7 2013 In addition to ER stress, GS also stimulates autophagy through lowering ATP and activating the canonical LKB1-AMPK energy sensing pathway as well as through increasing reactive oxygen species resulting in the activation of ERK. Reactive Oxygen Species 168-191 mitogen-activated protein kinase 1 Homo sapiens 223-226 23500541-9 2013 This inhibition correlates with dramatically depleted ATP levels, and occurs through reduction of the PI3K III-Beclin1 complex for autophagy initiation, blockage of the conjugation of ATG12 to ATG5 for autophagosome expansion, as well as inhibition of the functional lysosomal compartment for autophagic degradation. Adenosine Triphosphate 54-57 autophagy related 12 Homo sapiens 184-189 23500541-9 2013 This inhibition correlates with dramatically depleted ATP levels, and occurs through reduction of the PI3K III-Beclin1 complex for autophagy initiation, blockage of the conjugation of ATG12 to ATG5 for autophagosome expansion, as well as inhibition of the functional lysosomal compartment for autophagic degradation. Adenosine Triphosphate 54-57 autophagy related 5 Homo sapiens 193-197