PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23301526-0	2014	Tacrolimus abrogates TGF-beta1-induced type I collagen production in normal human fibroblasts through suppressing p38MAPK signalling pathway: implications on treatment of chronic atopic dermatitis lesions.	Tacrolimus	0-10	transforming growth factor beta 1	Homo sapiens	21-30	
23301526-4	2014	Tacrolimus (FK506) ointment has been reported to be effective for treating AD as well as some TGF-beta1-induced fibrotic diseases.	Tacrolimus	0-10	transforming growth factor beta 1	Homo sapiens	94-103	
23301526-4	2014	Tacrolimus (FK506) ointment has been reported to be effective for treating AD as well as some TGF-beta1-induced fibrotic diseases.	Tacrolimus	12-17	transforming growth factor beta 1	Homo sapiens	94-103	
23301526-5	2014	OBJECTIVES: To evaluate the effect of tacrolimus on TGF-beta1-stimulated cultured normal human dermal fibroblasts and explore the potential signalling pathways involved.	Tacrolimus	38-48	transforming growth factor beta 1	Homo sapiens	52-61	
23301526-9	2014	RESULTS: Our results revealed that the increased expressions of transforming growth factor-beta receptor I (TGF-betaRI) and TGF-betaRII in TGF-beta1-treated fibroblasts were suppressed by tacrolimus treatment.	Tacrolimus	188-198	transforming growth factor beta 1	Homo sapiens	139-148	
23301526-10	2014	In addition, tacrolimus significantly inhibited fibroblast proliferation enhanced by TGF-beta1.	Tacrolimus	13-23	transforming growth factor beta 1	Homo sapiens	85-94	
23301526-11	2014	TGF-beta1 increased type I collagen production, and this enhancing effect was suppressed by tacrolimus.	Tacrolimus	92-102	transforming growth factor beta 1	Homo sapiens	0-9	
23301526-12	2014	The down-regulation of MMP-1 and up-regulation of TIMP-1 induced by TGF-beta1 were reversed by tacrolimus.	Tacrolimus	95-105	transforming growth factor beta 1	Homo sapiens	68-77	
23301526-13	2014	The increase in phosphorylated p38 mitogen-activated protein kinase (p38MAPK) expression stimulated by TGF-beta1 was down-regulated by tacrolimus.	Tacrolimus	135-145	transforming growth factor beta 1	Homo sapiens	103-112	
23301526-15	2014	CONCLUSIONS: The present results demonstrated that tacrolimus significantly inhibited physiological functions of fibroblasts enhanced by TGF-beta1 in vitro.	Tacrolimus	51-61	transforming growth factor beta 1	Homo sapiens	137-146