PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23286227-1	2013	The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Polychlorinated Dibenzodioxins	225-260	aryl hydrocarbon receptor	Homo sapiens	4-29	
23286227-1	2013	The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Polychlorinated Dibenzodioxins	225-260	aryl hydrocarbon receptor	Homo sapiens	31-34	
23286227-1	2013	The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Polychlorinated Dibenzodioxins	262-266	aryl hydrocarbon receptor	Homo sapiens	4-29	
23286227-1	2013	The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	Polychlorinated Dibenzodioxins	262-266	aryl hydrocarbon receptor	Homo sapiens	31-34	
23286227-4	2013	The ligand-binding cavity of the fish AHR exhibits differences from those of mammalian and avian AHRs, suggesting a slightly different TCDD binding mode.	Polychlorinated Dibenzodioxins	135-139	aryl hydrocarbon receptor	Homo sapiens	38-41	
23286227-5	2013	Comparison of the internal cavity in the LBD model of zebrafish (zf) AHR2, which binds TCDD with high affinity, to that of zfAHR1a, which does not bind TCDD, revealed that the latter has a dramatically shortened binding cavity due to the side chains of three residues (Tyr296, Thr386, and His388) that reduce the amount of internal space available to TCDD.	Polychlorinated Dibenzodioxins	87-91	aryl hydrocarbon receptor 2	Danio rerio	69-73	
23286227-6	2013	Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA.	Polychlorinated Dibenzodioxins	133-137	aryl hydrocarbon receptor 1a	Danio rerio	40-47	
23286227-6	2013	Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA.	Polychlorinated Dibenzodioxins	133-137	aryl hydrocarbon receptor 2	Danio rerio	68-74	
23286227-6	2013	Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA.	Polychlorinated Dibenzodioxins	133-137	aryl hydrocarbon receptor 1a	Danio rerio	40-46	
23286227-6	2013	Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA.	Polychlorinated Dibenzodioxins	153-157	aryl hydrocarbon receptor 1a	Danio rerio	40-47	
23286227-6	2013	Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA.	Polychlorinated Dibenzodioxins	153-157	aryl hydrocarbon receptor 2	Danio rerio	68-74	
23286227-6	2013	Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA.	Polychlorinated Dibenzodioxins	153-157	aryl hydrocarbon receptor 1a	Danio rerio	40-46