PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22898570-1	2013	The regulation of cell growth and protein biosynthesis is triggered by the mammalian target of rapamycin complex 1 (mTORC1) responding to amino acids, especially leucine.	Leucine	162-169	CREB regulated transcription coactivator 1	Mus musculus	116-122	
22898570-3	2013	We analyzed whether the free intracellular leucine availability, a metabolite of leucine catabolism or the process of leucine oxidation activates mTORC1 signaling.	Leucine	43-50	CREB regulated transcription coactivator 1	Mus musculus	146-152	
22898570-4	2013	We further investigated whether mTORC1 signaling is subject to altered regulation in disturbed leucine metabolism.	Leucine	95-102	CREB regulated transcription coactivator 1	Mus musculus	32-38	
22898570-7	2013	The leucine/glutamine antiporter SLC7A5/SLC3A2 and the amino acid sensor MAP4K3 were identified as crucial determinants of signaling leucine availability to downstream targets.	Leucine	4-11	solute carrier family 7 member 5	Homo sapiens	33-39	
22898570-7	2013	The leucine/glutamine antiporter SLC7A5/SLC3A2 and the amino acid sensor MAP4K3 were identified as crucial determinants of signaling leucine availability to downstream targets.	Leucine	4-11	solute carrier family 3 member 2	Homo sapiens	40-46	
22898570-10	2013	Our data provide evidence that mechanisms determining intracellular leucine availability and the amino acid sensor MAP4K3 are key upstream modulators of nutrient-sensitive mTORC1 signaling, whereas specific leucine metabolites or leucine oxidation rates do not play a role.	Leucine	68-75	CREB regulated transcription coactivator 1	Mus musculus	172-178	
22898570-11	2013	In human fibroblasts deficient in leucine catabolic steps, we observed regulation consistent with sustaining a more efficient MAP4K3 and mTOR-S6K1 signaling.	Leucine	34-41	mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens	126-132	
22898570-11	2013	In human fibroblasts deficient in leucine catabolic steps, we observed regulation consistent with sustaining a more efficient MAP4K3 and mTOR-S6K1 signaling.	Leucine	34-41	ribosomal protein S6 kinase B1	Homo sapiens	142-146