PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22829846-3 2012 While it has been long established that NSAIDs cause inhibition of cyclooxygenase-1 (COX-1), leading to excessive metabolism of arachidonic acid (AA) to cysteinyl-leukotrienes (cys-LTs), there is now evidence that both cytokines and staphylococcus superantigens amplify the inflammatory process exacerbating the disease. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 67-83 22829846-3 2012 While it has been long established that NSAIDs cause inhibition of cyclooxygenase-1 (COX-1), leading to excessive metabolism of arachidonic acid (AA) to cysteinyl-leukotrienes (cys-LTs), there is now evidence that both cytokines and staphylococcus superantigens amplify the inflammatory process exacerbating the disease. Arachidonic Acid 128-144 prostaglandin-endoperoxide synthase 1 Homo sapiens 85-90