PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22827572-3 2012 Through screening and lead optimization using the human PERK crystal structure, we discovered compound 38 (GSK2606414), an orally available, potent, and selective PERK inhibitor. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine 107-117 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 56-60 22827572-3 2012 Through screening and lead optimization using the human PERK crystal structure, we discovered compound 38 (GSK2606414), an orally available, potent, and selective PERK inhibitor. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine 107-117 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 163-167