PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22768248-0 2012 Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. Fatty Acids 11-22 ghrelin Mus musculus 44-51 22768248-2 2012 The octanoylation at Ser(3) is essential for ghrelin"s biological effects but the mechanisms involved in the octanoylation are unknown. ser(3) 21-27 ghrelin Mus musculus 45-52 22768248-3 2012 We investigated whether the gustatory G-protein, alpha-gustducin, and the free fatty acid receptors GPR40 and GPR120 are involved in the fatty acid sensing mechanisms of the ghrelin cell. Fatty Acids 79-89 free fatty acid receptor 1 Mus musculus 100-105 22768248-3 2012 We investigated whether the gustatory G-protein, alpha-gustducin, and the free fatty acid receptors GPR40 and GPR120 are involved in the fatty acid sensing mechanisms of the ghrelin cell. Fatty Acids 79-89 ghrelin Mus musculus 174-181 22768248-7 2012 The role of GPR120 in the effect of medium and long chain fatty acids on the release of ghrelin was studied in the ghrelinoma cell line, MGN3-1. long chain fatty acids 47-69 ghrelin Mus musculus 88-95 22768248-8 2012 The effect of the GPR40 agonist, MEDICA16, and the GPR120 agonist, grifolic acid, on ghrelin release was studied both in vitro and in vivo. grifolic acid 67-80 ghrelin Mus musculus 85-92 22768248-11 2012 GPR40 was colocalized with desoctanoyl but not with octanoyl ghrelin, alpha-gustducin or alpha-transducin positive cells in the stomach. desoctanoyl 27-38 free fatty acid receptor 1 Mus musculus 0-5 22768248-13 2012 Addition of octanoic acid or alpha-linolenic acid to MGN3-1 cells increased and decreased octanoyl ghrelin levels, respectively. octanoic acid 12-25 ghrelin Mus musculus 99-106 22768248-13 2012 Addition of octanoic acid or alpha-linolenic acid to MGN3-1 cells increased and decreased octanoyl ghrelin levels, respectively. alpha-Linolenic Acid 29-49 ghrelin Mus musculus 99-106 22768248-15 2012 MEDICA16 and grifolic acid did not affect ghrelin secretion in vitro but oral administration of grifolic acid increased plasma ghrelin levels. grifolic acid 96-109 ghrelin Mus musculus 127-134 22768248-16 2012 CONCLUSION: This study provides the first evidence that alpha-gustducin is involved in the octanoylation of ghrelin and shows that the ghrelin cell can sense long- and medium-chain fatty acids directly. long- and medium-chain fatty acids 158-192 guanine nucleotide binding protein, alpha transducing 3 Mus musculus 56-71 22768248-16 2012 CONCLUSION: This study provides the first evidence that alpha-gustducin is involved in the octanoylation of ghrelin and shows that the ghrelin cell can sense long- and medium-chain fatty acids directly. long- and medium-chain fatty acids 158-192 ghrelin Mus musculus 135-142