PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2274641-1	1990	The prolactin (PRL) response to challenge with buspirone hydrochloride, a serotonin1a (5-HT1a) receptor agonist, was examined in 5 healthy male volunteers and in 10 healthy male and female patients with primary DSM-III personality disorder.	Buspirone	47-70	prolactin	Homo sapiens	4-13	
2274641-1	1990	The prolactin (PRL) response to challenge with buspirone hydrochloride, a serotonin1a (5-HT1a) receptor agonist, was examined in 5 healthy male volunteers and in 10 healthy male and female patients with primary DSM-III personality disorder.	Buspirone	47-70	prolactin	Homo sapiens	15-18	
2274641-3	1990	completely suppressed the maximal PRL response to buspirone challenge.	Buspirone	50-59	prolactin	Homo sapiens	34-37	
2274641-4	1990	Pretreatment with the nonselective beta-adrenergic/5-HT1-like antagonist, pindolol suppressed the maximal PRL response to buspirone challenge depending upon dose (i.e., between 49 to 90% suppression at best dose).	Buspirone	122-131	prolactin	Homo sapiens	106-109	
2274641-5	1990	In personality disorder patients, PRL responses to buspirone challenge correlated inversely with self-assessed "irritability" (r = -.76, n = 10, p less than .01).	Buspirone	51-60	prolactin	Homo sapiens	34-37	
2274641-6	1990	These data suggest that the PRL response to buspirone challenge reflects the responsivity of 5-HT1a receptors in the limbic-hypothalamus in humans and that reduced sensitivity of these receptors is associated with an important component of impulsive aggressive behaviors in personality disorder patients.	Buspirone	44-53	prolactin	Homo sapiens	28-31