PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22740861-0	2012	Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study.	Irinotecan	11-21	proteasome 26S subunit, non-ATPase 1	Homo sapiens	44-47	
22740861-1	2012	Irinotecan hydrochloride (CPT-11) is reported to be involved in the downregulation of thymidylate synthase (TS), a target molecule of 5-fluorouracil (5-FU) and oral fluoropyrimidine S-1.	Irinotecan	0-24	proteasome 26S subunit, non-ATPase 1	Homo sapiens	182-185	
22740861-1	2012	Irinotecan hydrochloride (CPT-11) is reported to be involved in the downregulation of thymidylate synthase (TS), a target molecule of 5-fluorouracil (5-FU) and oral fluoropyrimidine S-1.	Irinotecan	26-32	proteasome 26S subunit, non-ATPase 1	Homo sapiens	182-185	
22740861-2	2012	Therefore, we hypothesized that a preceding administration of CPT-11 against S-1-resistant tumors may recover sensitivity to S-1.	Irinotecan	62-68	proteasome 26S subunit, non-ATPase 1	Homo sapiens	77-80	
22740861-2	2012	Therefore, we hypothesized that a preceding administration of CPT-11 against S-1-resistant tumors may recover sensitivity to S-1.	Irinotecan	62-68	proteasome 26S subunit, non-ATPase 1	Homo sapiens	125-128