PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22678893-2 2012 Upon contact with nTreg cells, cAMP is transferred from nTreg cells into activated target CD4(+) T cells and/or antigen-presenting cells (APCs) via gap junctions to suppress CD4(+) T-cell function. Cyclic AMP 31-35 CD4 molecule Homo sapiens 90-93 22678893-2 2012 Upon contact with nTreg cells, cAMP is transferred from nTreg cells into activated target CD4(+) T cells and/or antigen-presenting cells (APCs) via gap junctions to suppress CD4(+) T-cell function. Cyclic AMP 31-35 CD4 molecule Homo sapiens 175-178 22678893-5 2012 In addition to its suppressive effects mediated via ICER, cAMP can also modulate the levels of surface-expressed cytotoxic T lymphocyte antigen-4 (CTLA-4) and its cognate B7 ligands on conventional CD4(+) T cells and/or APCs, fine-tuning suppression. Cyclic AMP 58-62 CD4 molecule Homo sapiens 198-201