PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22640031-2 2012 Preclinical data showed that the Akt inhibitor, perifosine, sensitized MM cells to lenalidomide and dexamethasone, providing the rationale for this Phase I, multicentre, single-arm study to assess the safety and determine the maximum-tolerated dose (MTD) of perifosine-lenalidomide-dexamethasone in relapsed and relapsed/refractory MM. Dexamethasone 100-113 AKT serine/threonine kinase 1 Homo sapiens 33-36 22640031-2 2012 Preclinical data showed that the Akt inhibitor, perifosine, sensitized MM cells to lenalidomide and dexamethasone, providing the rationale for this Phase I, multicentre, single-arm study to assess the safety and determine the maximum-tolerated dose (MTD) of perifosine-lenalidomide-dexamethasone in relapsed and relapsed/refractory MM. Dexamethasone 282-295 AKT serine/threonine kinase 1 Homo sapiens 33-36