PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22483273-1 2012 Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity choline transporter CHT is essential for providing choline as substrate for synthesis of acetylcholine (ACh); ACh is used by cholinergic neurons to communicate information to a wide range of tissues in central and peripheral nervous systems. Choline 0-7 solute carrier family 5 member 7 Homo sapiens 106-109 22483273-1 2012 Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity choline transporter CHT is essential for providing choline as substrate for synthesis of acetylcholine (ACh); ACh is used by cholinergic neurons to communicate information to a wide range of tissues in central and peripheral nervous systems. Sodium 55-61 solute carrier family 5 member 7 Homo sapiens 106-109 22483273-1 2012 Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity choline transporter CHT is essential for providing choline as substrate for synthesis of acetylcholine (ACh); ACh is used by cholinergic neurons to communicate information to a wide range of tissues in central and peripheral nervous systems. Choline 20-27 solute carrier family 5 member 7 Homo sapiens 106-109 22483273-1 2012 Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity choline transporter CHT is essential for providing choline as substrate for synthesis of acetylcholine (ACh); ACh is used by cholinergic neurons to communicate information to a wide range of tissues in central and peripheral nervous systems. Acetylcholine 175-188 solute carrier family 5 member 7 Homo sapiens 106-109 22483273-1 2012 Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity choline transporter CHT is essential for providing choline as substrate for synthesis of acetylcholine (ACh); ACh is used by cholinergic neurons to communicate information to a wide range of tissues in central and peripheral nervous systems. Acetylcholine 190-193 solute carrier family 5 member 7 Homo sapiens 106-109 22483273-1 2012 Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity choline transporter CHT is essential for providing choline as substrate for synthesis of acetylcholine (ACh); ACh is used by cholinergic neurons to communicate information to a wide range of tissues in central and peripheral nervous systems. Acetylcholine 196-199 solute carrier family 5 member 7 Homo sapiens 106-109 22483273-4 2012 Thus, choline uptake activity is determined largely by the plasma membrane CHT level, and this is finely controlled by a balance between internalization and recycling of CHT proteins in endosomal compartments. Choline 6-13 solute carrier family 5 member 7 Homo sapiens 75-78 22483273-4 2012 Thus, choline uptake activity is determined largely by the plasma membrane CHT level, and this is finely controlled by a balance between internalization and recycling of CHT proteins in endosomal compartments. Choline 6-13 solute carrier family 5 member 7 Homo sapiens 170-173 22483273-5 2012 CHT proteins are also in synaptic vesicle membranes, thereby allowing cell surface CHT levels to increase rapidly in conjunction with exocytotic transmitter release to provide enhanced choline for ACh re-synthesis. Choline 185-192 solute carrier family 5 member 7 Homo sapiens 0-3 22483273-5 2012 CHT proteins are also in synaptic vesicle membranes, thereby allowing cell surface CHT levels to increase rapidly in conjunction with exocytotic transmitter release to provide enhanced choline for ACh re-synthesis. Choline 185-192 solute carrier family 5 member 7 Homo sapiens 83-86 22483273-5 2012 CHT proteins are also in synaptic vesicle membranes, thereby allowing cell surface CHT levels to increase rapidly in conjunction with exocytotic transmitter release to provide enhanced choline for ACh re-synthesis. Acetylcholine 197-200 solute carrier family 5 member 7 Homo sapiens 0-3 22483273-5 2012 CHT proteins are also in synaptic vesicle membranes, thereby allowing cell surface CHT levels to increase rapidly in conjunction with exocytotic transmitter release to provide enhanced choline for ACh re-synthesis. Acetylcholine 197-200 solute carrier family 5 member 7 Homo sapiens 83-86 22483273-9 2012 The critical role of CHT in maintaining cholinergic transmission indicates that it could be a target for therapeutic intervention to promote ACh synthesis, but mechanisms by which this can be accomplished have not been adequately addressed. Acetylcholine 141-144 solute carrier family 5 member 7 Homo sapiens 21-24