PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22431524-3 2012 Here we show that when detached from the matrix, untransformed mammary epithelial cells undergo metabolic reprogramming by markedly upregulating pyruvate dehydrogenase (PDH) kinase 4 (PDK4) through estrogen-related receptor gamma (ERRgamma), thereby inhibiting PDH and attenuating the flux of glycolytic carbon into mitochondrial oxidation. Carbon 304-310 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 169-172