PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22421369-1 2012 ZRBA1 is a quinazoline-based molecule termed "combi-molecule" designed to block the epidermal growth factor receptor (EGFR) and further degrade to FD105, an EGFR inhibitor plus a DNA-alkylating agent. Quinazolines 11-22 epidermal growth factor receptor Homo sapiens 84-116 22421369-1 2012 ZRBA1 is a quinazoline-based molecule termed "combi-molecule" designed to block the epidermal growth factor receptor (EGFR) and further degrade to FD105, an EGFR inhibitor plus a DNA-alkylating agent. Quinazolines 11-22 epidermal growth factor receptor Homo sapiens 118-122 22421369-1 2012 ZRBA1 is a quinazoline-based molecule termed "combi-molecule" designed to block the epidermal growth factor receptor (EGFR) and further degrade to FD105, an EGFR inhibitor plus a DNA-alkylating agent. Quinazolines 11-22 epidermal growth factor receptor Homo sapiens 157-161 22421369-9 2012 This study conclusively demonstrated that designing molecules as prodrugs of high levels of quinazoline inhibitors of EGFR and bifunctional DNA cross-linking species is a valid strategy to enhance the potency of mixed EGFR-DNA-targeting combi-molecules. Quinazolines 92-103 epidermal growth factor receptor Homo sapiens 118-122 22421369-9 2012 This study conclusively demonstrated that designing molecules as prodrugs of high levels of quinazoline inhibitors of EGFR and bifunctional DNA cross-linking species is a valid strategy to enhance the potency of mixed EGFR-DNA-targeting combi-molecules. Quinazolines 92-103 epidermal growth factor receptor Homo sapiens 218-222