PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22414858-6 2012 The restricted distribution of c-Fos to these areas, all of which are directly or indirectly involved in acute stress regulation after a single dose of ispronicline, supports earlier studies that the alpha4beta2 receptors are strongly involved in nicotine-dependent activation of the hypothalamo-pituitary adrenocortical axis. Nicotine 247-255 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36