PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22388934-5 2012 Using mouse primary PASMCs derived from knock-in mice, we demonstrated that BMPR-II dysfunction promotes the activation of small mothers against decapentaplegia-independent mitogen-activated protein kinase (MAPK) pathways via TGFbeta-associated kinase 1 (TAK1), resulting in a pro-proliferative and anti-apoptotic response. pasmcs 20-26 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 76-83 22388934-7 2012 In both hypoxia and monocrotaline-induced PAH rat models, which display reduced levels of bmpr2 transcripts, this study further indicates that the TGFbeta-MAPK axis is activated in lungs following elevation of both expression and phosphorylation of the TAK1 protein. Monocrotaline 20-33 bone morphogenetic protein receptor type 2 Rattus norvegicus 90-95 22388934-7 2012 In both hypoxia and monocrotaline-induced PAH rat models, which display reduced levels of bmpr2 transcripts, this study further indicates that the TGFbeta-MAPK axis is activated in lungs following elevation of both expression and phosphorylation of the TAK1 protein. Monocrotaline 20-33 transforming growth factor beta 1 Homo sapiens 147-154 22388934-7 2012 In both hypoxia and monocrotaline-induced PAH rat models, which display reduced levels of bmpr2 transcripts, this study further indicates that the TGFbeta-MAPK axis is activated in lungs following elevation of both expression and phosphorylation of the TAK1 protein. Monocrotaline 20-33 mitogen activated protein kinase kinase kinase 7 Rattus norvegicus 253-257