PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22328075-5 2012 The result of this study indicates that the incorporation of the 4-(methylsulfonyl)aniline pharamacophore into naproxen, indomethacine, diclofenac and mefanamic acid maintained their anti-inflammatory activity and may increase selectivity towards the COX-2 enzyme which will be confirmed in the future by assessing COX-2: COX-1 inhibitory ratios using a whole blood assay. Naproxen 111-119 cytochrome c oxidase I, mitochondrial Rattus norvegicus 322-327