PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21780830-5 2011 Studies with cellular models expressing single transporters showed that OATP2B1 expression stimulated uptake of fexofenadine at pH 6.0. fexofenadine 112-124 solute carrier organic anion transporter family member 2B1 Homo sapiens 72-79 21780830-6 2011 Apical uptake of fexofenadine into Caco-2 cells was decreased by 45% by pretreatment with estrone 3-sulfate, an OATP inhibitor, at pH 6.0 but not at pH 7.4, indicating that OATP2B1 mediates apical uptake of fexofenadine into these cells. fexofenadine 17-29 solute carrier organic anion transporter family member 2B1 Homo sapiens 173-180 21780830-6 2011 Apical uptake of fexofenadine into Caco-2 cells was decreased by 45% by pretreatment with estrone 3-sulfate, an OATP inhibitor, at pH 6.0 but not at pH 7.4, indicating that OATP2B1 mediates apical uptake of fexofenadine into these cells. fexofenadine 207-219 solute carrier organic anion transporter family member 2B1 Homo sapiens 173-180 21780830-11 2011 The results provide a novel insight into a vectorial transport system mainly consisting of apical OATP2B1 and basolateral MRP3 that may play an important role in delivering hydrophilic anionic and zwitterionic drugs such as pravastatin and fexofenadine into systemic circulation upon oral administration. fexofenadine 240-252 solute carrier organic anion transporter family member 2B1 Homo sapiens 98-105