PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21625550-0 2011 Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages. Lycopene 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 33-37 21625550-3 2011 The aim of this study was to investigate the role of lycopene on the production of the pro-inflammatory cytokine IL-8 induced by cigarette smoke and the possible mechanisms implicated. Lycopene 53-61 C-X-C motif chemokine ligand 8 Homo sapiens 113-117 21625550-6 2011 Lycopene pre-treatment resulted in a significant inhibition of CSE-induced IL-8 expression at both mRNA and protein levels. Lycopene 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 21625550-13 2011 Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB. Lycopene 39-47 C-X-C motif chemokine ligand 8 Homo sapiens 70-74 21625550-15 2011 The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE. Lycopene 15-23 C-X-C motif chemokine ligand 8 Homo sapiens 38-42