PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21613472-4 2011 In turn, hippocampal nNOS-derived nitric oxide (NO) significantly downregulated local glucocorticoid receptor expression through both soluble guanylate cyclase (sGC)/cGMP and peroxynitrite (ONOO(-))/extracellular signal-regulated kinase signal pathways, and therefore elevated hypothalamic corticotrophin-releasing factor, a peptide that governs the hypothalamic-pituitary-adrenal axis. onoo 190-194 nitric oxide synthase 1 Homo sapiens 21-25