PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21605164-6	2011	Notably, the dual actions of the MT(1) receptor-mediated antiproliferative signaling, leading to down-regulation of activated AR signaling and up-regulation of p27(Kip1) , constitute the mechanistic basis for the potential use of melatonin in chemoprevention of prostate cancer, as well as in a novel therapeutic strategy, comprising a combination of melatonin repletion and androgen depletion, for the treatment of advanced or relapsed disease.	Melatonin	230-239	cyclin dependent kinase inhibitor 1B	Homo sapiens	164-168