PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21602124-8 2011 CONCLUSION: APN may decrease tyrosine phosphorylation of IRS-1 via the IKK/NFkappaB pathway and inhibit insulin signaling pathway in the liver, which contributes to hyperlipidemia, hyperglycemia and development of type 2 diabetes. Tyrosine 29-37 insulin receptor substrate 1 Rattus norvegicus 57-62