PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21595977-6 2011 A robust autophagy was observed in the cells treated with beta-elemene; it was characterized by the increase of punctate LC3 dots, the cellular morphology, and the increased levels of LC3-II protein. beta-elemene 58-70 microtubule associated protein 1 light chain 3 alpha Homo sapiens 121-124 21595977-6 2011 A robust autophagy was observed in the cells treated with beta-elemene; it was characterized by the increase of punctate LC3 dots, the cellular morphology, and the increased levels of LC3-II protein. beta-elemene 58-70 microtubule associated protein 1 light chain 3 alpha Homo sapiens 184-187 21595977-7 2011 Further study showed that beta-elemene treatment up-regulated Atg5-Atg12 conjugated protein but had little effect on other autophagy-related proteins. beta-elemene 26-38 autophagy related 5 Homo sapiens 62-66 21595977-7 2011 Further study showed that beta-elemene treatment up-regulated Atg5-Atg12 conjugated protein but had little effect on other autophagy-related proteins. beta-elemene 26-38 autophagy related 12 Homo sapiens 67-72 21595977-8 2011 PI3K/Akt/mTOR/p70S6K1 activity was inhibited by beta-elemene. beta-elemene 48-60 AKT serine/threonine kinase 1 Homo sapiens 5-8 21595977-8 2011 PI3K/Akt/mTOR/p70S6K1 activity was inhibited by beta-elemene. beta-elemene 48-60 mechanistic target of rapamycin kinase Homo sapiens 9-13 21595977-9 2011 Knockdown of Beclin 1 with small interfering RNA, or co-treatment with the autophagy inhibitor, 3-methyladenine or chlorochine enhanced significantly the antitumor effects of beta-elemene. beta-elemene 175-187 beclin 1 Homo sapiens 13-21