PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21571003-1 2011 Sustained morphine treatment has been shown to produce paradoxical pain sensitization (opioid-induced hyperalgesia) and also causes increase in spinal pain neurotransmitter, such as calcitonin gene related peptide (CGRP), concentration in experimental animals. Morphine 10-18 calcitonin-related polypeptide alpha Rattus norvegicus 182-213 21571003-1 2011 Sustained morphine treatment has been shown to produce paradoxical pain sensitization (opioid-induced hyperalgesia) and also causes increase in spinal pain neurotransmitter, such as calcitonin gene related peptide (CGRP), concentration in experimental animals. Morphine 10-18 calcitonin-related polypeptide alpha Rattus norvegicus 215-219 21571003-6 2011 pretreatment of rats with a PKA-selective small interference RNA (siRNA) mixture significantly attenuates sustained morphine-mediated augmentation of spinal CGRP immunoreactivity, thermal hyperalgesia, mechanical allodynia and antinociceptive tolerance. Morphine 116-124 calcitonin-related polypeptide alpha Rattus norvegicus 157-161