PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21413019-2 2011 The rate-limiting polyamine biosynthetic enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase, are essential for mammalian development, with knockout of the genes encoding these enzymes, Odc1 and Amd1, causing early embryonic lethality in mice. Polyamines 18-27 adenosylmethionine decarboxylase 1 Homo sapiens 221-225 21413019-5 2011 In muscle, androgens act via the androgen receptor to regulate expression of polyamine biosynthetic enzyme genes, including Odc1 and Amd1, which may be one mechanism via which androgens promote muscle growth. Polyamines 77-86 adenosylmethionine decarboxylase 1 Homo sapiens 133-137