PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21352586-0 2011 Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Cholecalciferol 47-57 interleukin 6 Mus musculus 84-88 21352586-4 2011 We examined the effects of vitamin D3 and vitamin E supplementation on levels of IL-6 and IL-10 (as a marker of anti-inflammatory cytokines since, a balance between pro- and anti-inflammatory cytokines is maintained) protein expression in adipose tissue of mice provided with an HFD. Cholecalciferol 27-37 interleukin 6 Mus musculus 81-85 21352586-5 2011 Additionally, we measured the effects of vitamin E and vitamin D3 treatment on LPS-stimulated 3T3-L1 adipocytes IL-6 and IL-10 secretion. Cholecalciferol 55-65 interleukin 6 Mus musculus 112-116 21352586-7 2011 A 24-hour treatment of vitamin D3 and vitamin E significantly reduced the IL-6 levels in the adipocytes culture medium without affecting IL-10 levels. Cholecalciferol 23-33 interleukin 6 Mus musculus 74-78 21352586-8 2011 CONCLUSIONS: Vitamin D3 and vitamin E supplementation in an HFD had an anti-inflammatory effect by decreasing IL-6 production in epididymal adipose tissue in mice and in 3T3-L1 adipocytes stimulated with LPS. Cholecalciferol 13-23 interleukin 6 Mus musculus 110-114