PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21164517-0	2011	The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.	AZD 1480	24-31	signal transducer and activator of transcription 3	Homo sapiens	39-44	
21164517-0	2011	The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.	AZD 1480	24-31	fibroblast growth factor receptor 3	Homo sapiens	49-54	
21164517-2	2011	We investigated the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK signal transduction and its biological consequences on the human myeloma-derived cell lines U266 and Kms.11.	AZD 1480	69-76	interleukin 6	Homo sapiens	81-85	
21164517-4	2011	These biological responses to AZD1480 are associated with concomitant inhibition of phosphorylation of JAK2, STAT3 and MAPK signaling proteins.	AZD 1480	30-37	Janus kinase 2	Homo sapiens	103-107	
21164517-4	2011	These biological responses to AZD1480 are associated with concomitant inhibition of phosphorylation of JAK2, STAT3 and MAPK signaling proteins.	AZD 1480	30-37	signal transducer and activator of transcription 3	Homo sapiens	109-114	
21164517-6	2011	Examination of a wider variety of myeloma cells (RPMI 8226, OPM-2, NCI-H929, Kms.18, MM1.S and IM-9), as well as primary myeloma cells, showed that AZD1480 has broad efficacy.	AZD 1480	148-155	plexin B2	Homo sapiens	85-88	
21164517-8	2011	Importantly, AZD1480 induces cell death of Kms.11 cells grown in the presence of HS-5 bone marrow (BM)-derived stromal cells and inhibits tumor growth in a Kms.11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels.	AZD 1480	13-20	fibroblast growth factor receptor 3	Mus musculus	225-230	
21164517-8	2011	Importantly, AZD1480 induces cell death of Kms.11 cells grown in the presence of HS-5 bone marrow (BM)-derived stromal cells and inhibits tumor growth in a Kms.11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels.	AZD 1480	13-20	Janus kinase 2	Mus musculus	240-244	
21164517-8	2011	Importantly, AZD1480 induces cell death of Kms.11 cells grown in the presence of HS-5 bone marrow (BM)-derived stromal cells and inhibits tumor growth in a Kms.11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels.	AZD 1480	13-20	signal transducer and activator of transcription 3	Mus musculus	254-259	
21164517-8	2011	Importantly, AZD1480 induces cell death of Kms.11 cells grown in the presence of HS-5 bone marrow (BM)-derived stromal cells and inhibits tumor growth in a Kms.11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels.	AZD 1480	13-20	cyclin D2	Mus musculus	264-273	
21164517-9	2011	In sum, AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 signaling in myeloma cells cultured alone or cocultured with BM stromal cells, and in vivo.	AZD 1480	8-15	fibroblast growth factor receptor 3	Homo sapiens	48-53	
21164517-9	2011	In sum, AZD1480 blocks proliferation, survival, FGFR3 and JAK/STAT3 signaling in myeloma cells cultured alone or cocultured with BM stromal cells, and in vivo.	AZD 1480	8-15	signal transducer and activator of transcription 3	Homo sapiens	62-67